Imagerie cellulaire et neuroanatomie

Électrophysiologie

Expérience postdoctorale

CNRS (France).

Programme de recherche

Dans mon laboratoire, nous étudions les changements développementaux se produisant au sein des systèmes sensorimoteurs qui sous-tendent les comportements chez les mammifères. Plus précisément, nous nous intéressons au rôle de l’activité électrique dans la maturation des réseaux locomoteurs, situés dans la moelle épinière, chez un opossum brésilien.

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English version

Academic background

Ph.D.: Sciences neurologiques, Université de Montréal (Quebec, Canada).

M.Sc.: Sciences biologiques, Université de Montréal (Quebec, Canada).

Postdoctoral fellow

CNRS (France).

Research interest

In my lab, we study the development of sensorimotor systems underlying mammalian behaviors. More precisely, we focus on the role of electrical activity in the maturation of spinal locomotor networks using a Brazilian opossum as a model.

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Publications choisies / Selected papers

Lemieux, M., T. Cabana, J.-F. Pflieger. 2010. Development of neuronal gap junction protein connexin36 in the spinal cord of the South American opossum, Monodelphis domestica. Brain Behavior and Evolution, 75: 23-32.

Lavallée, A., J.-F. Pflieger. 2009. Developmental expression of spontaneous activity in the spinal cord of postnatal opossums, Monodelphis domestica: A study using Sulforhodamine-101. Brain Research, 1282: 1-9.

Jean-Xavier, C., J.-F. Pflieger, S. Liaboeuf, L. Vinay. 2006. The ontogenetic switch from depolarizing to hyperpolarizing inhibitory post-synaptic potentials in rat lumbar motoneurons requires inputs from the brain. Journal of Neurophysiology, 96: 2274-2281.

Vinay, L., F. Ben-Mabrouk, F. Brocard, F. Clarac, C. Jean-Xaxier, J.-F. Pflieger, E. Pearlstein. 2005. Perinatal development of the motor systems involved in postural control. Neural Plasticity, 12: 131-139.

Clarac, F., E. Pearlstein, J.-F. Pflieger, L. Vinay. 2004. The in vitro neonatal spinal cord preparation: A new insight into mammalian locomotor mechanisms Journal of Comparative Physiology A, 190: 343-357.

Norreel, J.-C.*, J.-F. Pflieger*, E. Pearlstein, J. Simeoni-Alias, F. Clarac, L. Vinay. 2003. Reversible disorganization of the locomotor pattern after neonatal spinal cord transection in the rat. Journal of Neuroscience, 23: 1924-1932. (* Contribution équivalente.)

Vinay, L., F. Brocard, F. Clarac, J.-C. Norreel, E. Pearlstein, J.-F. Pflieger. 2002. Development of posture and locomotion: An interplay of endogenously generated activities and neurotrophic actions by descending pathways. Brain Research Reviews, 40: 118-129.

Pflieger, J.-F., F. Clarac, L. Vinay. 2002. Postural deficits and neuronal excitability changes induced by a short-term serotonin depletion during neonatal development in the rat. Journal of Neuroscience, 22(12): 5108-5117.

Article gagnant du concours de vulgarisation 2010 de l’Acfas, par Ha-Loan Phan, étudiante au laboratoire :
Phan H.-L. 2010. L’opossum Monodelphis domestica, un modèle qui marche.